Highlights

  • • Pre-existing mental disorders increases the risk of developing SUD.
  • • Prior SUD increases the risk of transitioning from use to use disorder.
  • • Highest rates of transition to SUD occurred among stimulant and opioid users.
  • • Mood and anxiety disorders increased the risk of transitioning to AUD and CUD.
  • • The rapidity of transition to SUD emphasizes the narrow opportunity to intervene.

Conclusion: The relative speed associated with the transition from use to SUD emphasizes the narrow window of time available to intervene, underscoring the urgency of early identification of mental health conditions and the timely provision of appropriate evidence-based interventions, which could potentially prevent the development of secondary SUDs.

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