JACC: Journal of the American College of Cardiology - Key Summary

  • Patients aged ≤50 years presenting with their first myocardial infarction were retrospectively analyzed to evaluate the prevalence of cocaine and marijuana use and the impact on clinical outcomes. The prevalence of the use of cocaine and/or marijuana was 10.7%. Compared with patients without a history substance use, those using cocaine and/or marijuana had…a significantly higher rate of tobacco use. There was a significant association between the use of cocaine and/or marijuana and elevated cardiovascular and all-cause mortality risk.
  • Approximately 10% of patients presenting with myocardial infarction at age ≤50 years are cocaine and/or marijuana users, and this substance use is associated with an increased mortality risk. Young adults presenting with a first myocardial infarction should be screened for substance use to allow intervention in order to prevent future cardiac events

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