These newer studies bring into precise focus recent work in the cannabis field showing that adolescent cannabis exposure results in loss of whole dendrites including synapses (4) and a reduction in post-synaptic glutamate A2 AMPA receptors (5)… Cannabis dependence is notable for its wide spectrum of clinical presentations including psychiatric, respiratory, immune, cardiac, vascular, bony, reproductive and malignant manifestations…Tetrahydrocannabinol, cannabidiol and other cannabinoids have prominent epigenetic footprints transmissible through human and rodent sperm for several generations (5) 

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