From the Abstract
Cannabis has been shown to be teratogenic in cells, animals and humans. Particular targets of prenatal exposure include brain, heart and blood vessels and chromosomal segregation…
Studies in cells, together with the above mentioned epidemiology, implicate cannabidiol, cannabichromene, cannabidivarin and other cannabinoids in significant genotoxicity and/or epigenotoxicity. Notch signalling has recently been shown to be altered by cannabinoids, which is highly pertinent to morphogenesis of the neuraxis and cardiovasculature, and also to congenital and inheritable cancer induction.
It is felt that subtle neurobehavioural psychosocial and educational deficits will likely be the most common expression of cannabinoid teratology at the population level.
The far reaching implications of this wide spectrum of neuroteratological, pediatric cardiological and other defects and deficits should be carefully considered in increasingly liberal paradigms. Hence it is shown that the disparate presentations of cannabis teratology relate directly and closely to the distribution of CB1R’s across the developing embryo and account for the polymorphous clinical presentations.
By JONATHAN BUCKS FOR THE MAIL ON SUNDAY 17 February 2019
The legal version of cannabis sold as a health product in the UK can get users ‘high’ and even make it dangerous to drive, a study has found.
Cannabis oils and capsules said to help reduce anxiety and pain are on sale in high street stores including Holland & Barrett and are used by more than 250,000 Britons.
They are sold legally because they contain no more than 0.2 per cent of the mind-altering substance tetrahydrocannabinol (THC), which is found in the illegal version of the drug.
But now scientists have found that the active ingredient in these products, cannabidiol (CBD), is also psychoactive. In the study, subjects used a vape to inhale different strains of cannabis.
Those using the version containing CBD but not illegal THC reported levels of intoxication three times that of those who used only a placebo. In addition, experts said subjects felt detached from reality.
Scientists from Wollongong University in Australia concluded that driving under the influence of CBD cannabis ‘may be harmful’.
The students who were current vape users were more likely to use other substances or to engage in sexual activity than were nonusers (Table 1). These data corroborate a recent study that showed an association between vaping and risky sexual, substance-use, and violence behaviors.5 These associations are not causal but suggest that certain students are inclined toward a variety of risky behaviors.
4 February 2019
Legalising cannabis leads to more university students flunking their exams. Striking evidence that legalising the drug negatively affects undergraduates’ behaviour and makes weaker students particularly likely to fall behind is provided by three new studies.
‘College students in medical marijuana law states spend approximately 20 per cent less time on education-related activities and 20 per cent more time on leisure activities than their counterparts in non-medical marijuana law states,’ the research team reported.
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